Development of progressive albuminuria in male Munich Wistar Frömter rats is androgen dependent
نویسندگان
چکیده
منابع مشابه
Development of progressive albuminuria in male Munich Wistar Frömter rats is androgen dependent.
Munich Wistar Frömter (MWF) rats develop spontaneous albuminuria that is linked to autosomal genetic loci and inherit a nephron deficit in both female and male animals, respectively. However, albuminuria and kidney damage are clearly more pronounced in males. Here we tested whether androgens and the androgen receptor influence albuminuria in male MWF. We first demonstrated in a pilot study that...
متن کاملNephron deficit is not required for progressive proteinuria development in the Munich Wistar Frömter rat.
The Munich Wistar Frömter (MWF) rat represents a genetic model with an inherited nephron deficit and exhibits mild hypertension and progressive albuminuria, which is more pronounced in males than females. Previously, we demonstrated in a consomic strain that replacement of a quantitative trait locus on chromosome 6 normalized the nephron deficit and suppressed albuminuria development, suggestin...
متن کاملInduction of albuminuria and kidney damage in SHR by transfer of chromosome 8 from Munich Wistar Frömter rats.
Inbred Munich Wistar Frömter [MWF/FubRkb (RGD:724569), MWF] rats develop progressive albuminuria with age that is under polygenetic influence. We previously identified a major albuminuria quantitative trait locus (QTL) on rat chromosome (RNO)8 in MWF. To test the independent role of QTL(s) for albuminuria development on RNO8, we generated a consomic SHR-Chr 8(MWF)/Rkb (SHR-8(MWF)) strain by tra...
متن کاملTissue expression of TRPC3 and TRPC6 in hypertensive Munich Wistar Frömter rats showing proteinuria.
BACKGROUND We investigated whether alterations of transient receptor potential canonical (TRPC) channel expression may be observed in tissues from Munich Wistar Frömter (MWF) rats showing proteinuria compared to control Wistar rats. METHODS TRPC expression was investigated in tissue from MWF and Wistar rats using quantitative real time PCR, immunoblotting, and immunohistochemistry. RESULTS ...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2015
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00008.2015